Abstract:  Specimens reported in this note represent the first discovery of Yuomys in Altun Shan. A new species, Yuomys altunensis, is established based on the following features: molars large and wide in proportion; metaconule distinctly separated from metacone, metaloph long, but incomplete; hypocone smaller than protocone; sinus extending to base of crown on lingual side; postcingulum connectting lingual side of metacone; metacone crescent and postcingulum short in M3. Yuomys altunensis is similar to Y. cavioides, Y. eleganes and Y. huangzhuangensis of late Middle Eocene in molar morphlogy. According to its evolutionary level, Y.altunensis is supposed as of late Middle Eocene in age, or slightly later.