Abstract: A new species of the large shrew, Beremendia jiangnanensis sp. nov., is described here. The materials were excavated from the Early Pleistocene deposits of Renzidong Cave located on the south bank of the lower reaches of the Yangtze River, near Fanchang County, Anhui Province, South China. The new species is the largest in the genus. It is morphologically more primitive than B. pohaiensis from China, but more advanced than the type species, B. fissidens, from the lower Pliocene of Europe. Beremendia was initially reported from the Pliocene of northern Europe. It had been widely distributed in the high latitude regions of Europe and central Asia with a high population density, and became extinct by the end of the Middle Pleistocene. In East Asia, however, it appeared later, and was only rarely reported from the Early Pleistocene of North China. The origin of the genus is still unclear. The new species is a typical member of Renzidong fauna which is composed of more than 70 mammals. The analyses of ecological and taxonomic composition of the fauna show that it is noticeably distinct from the known Early Pleistocene faunas from northern and southern China and the modern local fauna for the reason that it is characterized by the coexistence of both Palearctic and Oriental faunal elements. But the Palearctic elements are somewhat predominate. The occurrence of the Palearctic element, Beremendia, as well as Equus sanmeniensis, Hypolagus, Kowalskia, and Mimomys, in the present-day Oriental Region strongly indicates that there was a cooling event during the Early Pleistocene, which drove the Palearctic elements to migrate southwards to the south of Yangtze River. So the southern boundary of the Palearctic Realm was more southernly located than present then. The first discovery of the hygrophilous and cryophylactic large shrew, Beremendia, in the present-day Oriental Region of East China will be helpful to the study of the evolution of Beremendia, and will provide significant information on the shrew’s dispersal events during the Plio-Pleistocene climatic transition and the faunistic development of China during Pleistocene.