Abstract: Six Eocene localities in eastern China, ranging geographically fromJilin to Jiangsu provinces and in age from Irdinmanhan to late Sharamurunian or Ergilian, have yielded four genera (Haozi, Suomys, and Andersomys named as new here and Zelomys) assigned to the new rodent family Zelomyidae. The family is characterized by a primitive protrogomorphous2sciurognathous zygomasseteric structure and pauciserial incisor enamel, but the cheek teeth are precocious in development of hypocone and hypolophid. Later members of the family exhibit a development of buccal flattening to selenodonty of the cusps of the cheek teeth. Relationships of the new family are unclear, although some dental similarities suggest affinities with the Eomyidae. On the other hand, differences from eomyids may suggest that the zelomyids are an independently derived Asian Eocene family.